Current and Future Goals of the Big Data / Bioinformatics Group in Pediatric Adrenocortical Tumor Research
The Big Data and Bioinformatics research group focusing on pediatric adrenocortical tumors (ACT) is currently utilizing genomic and RNA sequencing (RNA-seq) datasets generated in collaboration between research centers in Brazil (Curitiba) and France. These efforts aim to deepen the molecular understanding of pediatric ACT by integrating high-throughput data from diverse populations.
The long-term objective is to consolidate and harmonize these datasets into a unified, comprehensive platform analogous to The Cancer Genome Atlas for adrenocortical carcinoma (TCGA-ACC). This integrated database will support large-scale multi-omics analyses, enable data sharing across international consortia, and provide a robust foundation for biomarker discovery, therapeutic target identification, and personalized treatment strategies in pediatric ACT.